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Abstract #1658

Empirical investigation of tools and imaging techniques for MRI-guided radiotherapy of lung cancer

Tatsuya J Arai 1 , Joris Nofiele 2 , Yam Ki Cheung 1 , Rajiv Chopra 2 , and Amit Sawant 1

1 Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, United States, 2 Radiology, UT Southwestern Medical Center, Dallas, Texas, United States

Respiratory motion management during the thoracoabdominal tumor treatment is one of the biggest challenges in modern image-guided radiation therapy (RT). MRI enables the long-term, dose-free, soft-tissue monitoring, representing clear advantages over x-ray-based imaging modalities. Given unique requirements of RT guidance-quality (high temporal resolution, and modest spatial resolution and SNR), we have been investigating the adaptation of k-t BLAST. We have also developed MRI-compatible, programmable, and externally and internally deformable lung motion phantom, which replicates respiratory motion traces acquired from lung cancer patients. To our knowledge, this is the first report of using k-t BLAST for lung cancer radiotherapy motion management.

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