Improving Noise Robustness of the Quantitative (q)BOLD Model.
Jan Sedlacik 1 , Dushyant Kumar 1 , and Jens Fiehler 1
University Medical Center Hamburg-Eppendorf,
Hamburg, Hamburg, Germany
The qBOLD model describes the effect of deoxygenated
blood of the capillary network on the signal decay.
However, the oxygenation extraction fraction (OEF) and
the deoxygenated blood volume (DBV) affect the signal
decay very similarly, which allows reliable OEF and DBV
estimation only for very high signal to noise ratios
(SNR>500). We improved the fitting of the qBOLD model by
obscuring the divergent global minimum root mean squared
errors (RMSE) by adding noise and finding an effective
global minimum by analyzing the local RMSE minima.
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