Magnetic Susceptibility (QSM) of Thalamic Sub-Nuclear Groups in Multiple Sclerosis
Ferdinand Schweser 1,2 , Devika Rattan 1 , Jesper Hagemeier 1 , Paul Polak 1 , Michael G Dwyer 1 , Christopher R Magnano 1 , and Robert Zivadinov 1,2
Buffalo Neuroimaging Analysis Center, Dept.
of Neurology, School of Medicine and Biomedical
Sciences, State University of New York at Buffalo,
Buffalo, NY, United States,
Molecular and Translational Imaging Center, Buffalo
CTRC, State University of New York at Buffalo, Buffalo,
NY, United States
In this work we investigate for the first time magnetic
susceptibility of the thalamic nuclear groups in
patients with multiple sclerosis (MS). Visibility of
thalamic nuclei on susceptibility maps considerably
varied between subjects, with highest visibility in CIS
and lowest visibility in SP-MS patients. These results
challenge current analysis strategies, which consider
basal ganglia nuclei as homogeneous structures. Careful
analysis of susceptibility in sub-nuclear groups
promises to provide more specific information on
pathology-related tissue changes.
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