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Abstract #1744

Initial experience using Magnetization Transfer with Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation (MT-IDEAL) in the abdomen.

David ML Lilburn 1 , Annette S Cooper 1 , Philip Murphy 2 , Christopher DJ Sinclair 3 , Scott I Semple 1,4 , and Robert L Janiczek 2

1 Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, East Lothian, United Kingdom, 2 Experimental Medicine Imaging, GlaxoSmithKline, Uxbridge, Middlesex, United Kingdom, 3 Institute of Neurology, University College London, London, United Kingdom, 4 BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, East Lothian, United Kingdom

Clinical magnetization transfer (MT) imaging within the abdomen has proven to lack sensitivity to detect liver fibrosis, possibly due to the confounding effect of lipid infiltration. Here a new method, which aims to remove the MT dependence on lipid concentration through integration of IDEAL fat/water separation, is employed. This study assesses the feasibility of MT-IDEAL imaging in the abdomen and compares resultant MTR values using standard MT methods and the MT-IDEAL paradigm. It is hoped that this will eventually allow for investigation of pathological changes in fat content and fibrosis within intra-abdominal organs in a wide range of diseases.

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