Initial experience using Magnetization Transfer with Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation (MT-IDEAL) in the abdomen.
David ML Lilburn 1 , Annette S Cooper 1 , Philip Murphy 2 , Christopher DJ Sinclair 3 , Scott I Semple 1,4 , and Robert L Janiczek 2
Clinical Research Imaging Centre, University
of Edinburgh, Edinburgh, East Lothian, United Kingdom,
Medicine Imaging, GlaxoSmithKline, Uxbridge, Middlesex,
of Neurology, University College London, London, United
Centre for Cardiovascular Science, University of
Edinburgh, Edinburgh, East Lothian, United Kingdom
Clinical magnetization transfer (MT) imaging within the
abdomen has proven to lack sensitivity to detect liver
fibrosis, possibly due to the confounding effect of
lipid infiltration. Here a new method, which aims to
remove the MT dependence on lipid concentration through
integration of IDEAL fat/water separation, is employed.
This study assesses the feasibility of MT-IDEAL imaging
in the abdomen and compares resultant MTR values using
standard MT methods and the MT-IDEAL paradigm. It is
hoped that this will eventually allow for investigation
of pathological changes in fat content and fibrosis
within intra-abdominal organs in a wide range of
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