Abstract #1747
Assessment of membrane fluidity using nuclear Overhauser enhancement mediated magnetization transfer
Xiao-Yong Zhang 1 , Jingping Xie 1 , Hua Li 1 , Junzhong Xu 1 , John C. Gore 1 , and Zhongliang Zu 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
The fluidity of cell membrane is an important
characteristic to assess, but to date there are no ways
to measure fluidity non-invasively in vivo. We have
observed a novel source of contrast at around -1.6 ppm
in z-spectra which is derived from nuclear Overhauser
enhancement (NOE) effects between water protons and
choline methyl protons which are in a restricted state
within cell membranes. Our measurements of this signal
modulation in different conditions show that
NOE-mediated MT signal correlates well with membrane
fluidity. This may provide a novel and non-invasive
imaging tool to assess changes in membrane fluidity.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
