Abstract #1757
Improved diagnosis of tumor tissues with QUESPOWR MRI
Edward A. Randtke 1 , Mark D. Pagel 1 , and Julio Crdenas-Rodrguez 1
1
Biomedical Engineering, University of
Arizona, Tucson, AZ, United States
The Quantification of Exchange as a function of
Saturation Power On the Water Resonance (QUESPOWR)
method is introduced as a simple way to detect tissues
with fast exchanging labile protons with small chemical
shifts relative to water. QUESPOWR is analyzed by the
linear HP-HW-QUESP method. Simulations and in vivo
studies showed that QUESPOWR contrast is specific for
tissues that exhibit low extracellular pH. QUESPOWR
might offer sensitivity and specificity for tumor
diagnosis.
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