Abstract #1759
Salicylic Acid based CEST agents for assessing brain perfusion territory and blood-brain barrier permeability
Xiaolei Song 1,2 , Piotr Walczak 1,2 , Xing Yang 1 , Xiaowei He 1,3 , Jeff W.M. Bulte 1,2 , Monica Pearl 1 , Peter C.M. van Zijl 1,2 , Martin Pomper 1 , Michael T. McMahon 1,2 , and Mirosław Janowski 1,4
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University, Baltimore, MD, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
3
School
of Information Sciences and Technology, Northwest
University, Xi'an, Shaanxi, China,
4
NeuroRepair
Department, MMRC, PAS, Warsaw, Poland
We used aspirin analogues as CEST contrast agents for
visualizing transcatheter brain perfusion territory.
During intra-arterial infusion of these contrast agents,
perfused brain parenchyma was highlighted in CEST
images, with the contrast quickly dropping to baseline
after infusion discontinuation. Three aspirin analogues
with distinct chemical shifts were evaluated. They were
detectable with the dose of ~11mg/kg producing >5%
contrast.. Upon intra-arterial infusion of high
osmolality mannitol, BBB disruption and parenchymal
retention of contrast agents was observed with the
territory matching that highlighted by control Gd-DTPA.
When subsequently infusing two agents, multi-color CEST
imaging allowed differentiation of their perfusion
territories.
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