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Abstract #1763

Quantitative Measurements of Amide Proton Transfer (APT) Signals and Tissue pH in Acute Ischemic Stroke

Dong-Hoon Lee 1 , Xiaoguang Liu 2 , Kai Zhang 1 , Yi Zhang 1 , Hye-Young Heo 1 , Wenxiao Li 1 , Raymond C. Koehler 2 , and Jinyuan Zhou 1

1 Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

APT imaging can be used to obtain tissue pH information. In this abstract, the quantitative measurements of APT signals and tissue pH in the acute ischemic stroke in rats were performed using extrapolated semi-solid magnetization transfer reference (EMR) signals. Our EMR approach may be helpful for more accurate APT pH quantification, and useful to understand and identify the characteristics of the ischemic stroke tissue.

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