Abstract #1885
Hyperpolarized ketone body metabolism in the in vivo rat heart
Angus Z Lau
1,2
, Jack J Miller
2,3
,
and Damian J Tyler
1,2
1
Department of Cardiovascular Medicine,
University of Oxford, Oxford, Oxfordshire, United
Kingdom,
2
Department
of Physiology, Anatomy, and Genetics, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
3
Department
of Physics, University of Oxford, Oxford, Oxfordshire,
United Kingdom
Building on previous work in the ex vivo rat heart, we
investigate the feasibility observing metabolism of
hyperpolarized acetoacetate in the in vivo rat heart.
Rats were scanned in the fed and fasted states. Spectra
were obtained every 1 s by surface coil localization to
the rat heart. We observe conversion of the acetoacetate
substrate into acetylcarnitine and interconversion into
the ketone body
-hydroxybutyrate.
Decarboxylation of acetoacetate into bicarbonate was
observed in the fed state, but not in the fasted state
(p<0.05).
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