Chemical exchange sensitive Spin-lock MRI of 3-O-methyl-D-glucose transport in brain
Hunter Mehrens 1 , Tao Jin 1 , and Seong-Gi Kim 1,2
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
for Neuroscience Imaging Research, Institue for Basic
Science, SKKU, Suwon, Korea
Recent studies showed an increase of chemical
exchange-sensitive spin-lock (CESL) MRI signal during
administration of 2-deoxy-glucose (2DG) with high
sensitivity. However, the toxicity of 2DG is a concern
for its clinical and preclinical application.
3-O-methyl-D-glucose (3OMG) is a non-metabolizable
glucose analogue with minimal toxicity, therefore, it
may have better potential as a contrast agent for the
study of glucose transport. In this work, we
demonstrated that 3OMG has similar chemical exchange
properties as 2DG and glucose, and unique advantages
relative to 2DG and glucose for in vivo studies.
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