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Abstract #1896

Detecting Nanodiamonds With DNP

David E J Waddington 1,2 , Mathieu Sarracanie 1,3 , Huiliang Zhang 3,4 , David Reilly 2 , Ronald L Walsworth 3,4 , and Matthew S Rosen 1,3

1 MGH/A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney, Sydney, NSW, Australia, 3 Department of Physics, Harvard University, Cambridge, MA, United States, 4 Harvard-Smithsonian Center for Astrophysics, Cambridge, MA, United States

This work aims to develop a new bio-probe based on the detection and tracking of nontoxic nanoparticles in biological environments. We report the first DNP enhancement of 1H in a nanodiamond/water solution at very low magnetic field. Overhauser-enhanced MRI (OMRI) utilizes the nuclear hyperpolarization of hydrogen to detect paramagnetic species. A 1.36 times enhancement of the 1H signal has been demonstrated in a 10%/wt solution of 100 nm natural nanodiamonds (Microdiamant) and DI water at 6.5 mT. This result will drive further research into the use of OMRI methodologies as a means of tracking nanoparticles in vivo.

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