PERFLUORO-15-CROWN-5-ETHER-LOADED HOLLOW MESOPOROUS SILICA SPHERES FOR 19F IN VIVO MRI
Ina Vernikouskaya 1,2 , Alexander Pochert 3 , Mika Linden 3 , and Volker Rasche 1,2
Internal Medicine II, University Hospital of
Ulm, Ulm, Baden-Wuerttemberg, Germany,
Animal MRI, University of Ulm, Ulm, Baden-Wuerttemberg,
Chemistry II, University of Ulm, Ulm,
19F offers great potential for in vivo quantification
without any background signal. Perfluorocarbons (PFC)
are typically applied due to their high 19F density.
Mesoporous amorphous silica nanoparticles have attracted
a lot of interest as drug carriers. However more
attractive particle architecture would be hollow spheres
with a porous shell that would allow higher PFC loadings
per particles. 250nm-sized hollow mesoporous silica
spheres (HMSS) are loaded with
perfluoro-15-crown-5-ether (PFCE) and evaluated as a new
contrast agent. PFCE-HMSS was characterized using MRI.
19F MRS was performed for quantification of the fluorine
load. A good fluorine signal localized in the liver and
in the brown fat was detected in vivo.
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