MRI detection of brain metastases labeled with iron oxide nanoflowers
Emily Alexandria Waters 1 , Luke Vistain 2 , Liang Mu 3 , Madhavi Puchalapalli 4 , Chad Haney 1 , Basma El Haddad 4 , Brandon Parker 3 , Thomas Meade 5 , and Jennifer Koblinski 4
Center for Advanced Molecular Imaging,
Northwestern University, Evanston, IL, United States,
Biological Sciences Program, Northwestern University,
Evanston, IL, United States,
University, IL, United States,
Virginia Commonwealth University, Richmond, VA, United
Northwestern University, Evanston, IL, United States
Though improved treatment of primary breast cancers has
increased patient survival, those diagnosed with brain
metastases typically survive only 2-16 months.
Understanding mechanisms of breast cancer metastasis to
the brain should improve patient outcomes. We modeled
metastasis in mice with intracardiac injection of
bioluminescent breast cancer cells that had been labeled
with iron oxide nanoflowers. We used IVIS to screen for
successful cell delivery to the brain and then MRI to
track the labeled cells for 7 days after their arrival
in the brain.
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