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Abstract #1930

Comparison of Iron-related MR Susceptibility and Transverse Relaxation Rates in the P19 Cell Model

Linshan Liu 1,2 , Neil Gelman 1,2 , Rebecca McGirr 1 , R. Terry Thompson 1,2 , Frank S Prato 1,2 , Lisa Hoffman 1,2 , and Donna E Goldhawk 1,2

1 Imaging program, Lawson Health Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada

MRI-based cell tracking techniques play an important role in developing cellular therapy. To improve these detection methods, we have examined MR measures of iron contrast in the P19 cell model. We measured the changes in apparent susceptibility (χa) and transverse relaxation rates (R2*, R2', R2) in cells cultured in the presence and absence of iron supplementation. Cellular iron content was determined using inductively-coupled plasma mass spectrometry and normalized to the amount of protein. The change in transverse relaxation rates showed a stronger correlation to iron levels than did the change in apparent susceptibility.

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