Abstract #1979
Mapping stimulus-evoked glutamate and lactate changes in the mouse brain using spectroscopic imaging
Aline Seuwen 1 , Aileen Schrter 1 , and Markus Rudin 1,2
1
Institute for Biomedical Engineering, ETH &
University of Zrich, Zrich, Switzerland,
2
Institute
for Pharmacology and Toxicology, University of Zrich,
Zrich, Switzerland
BOLD fMRI is an indirect readout for neuronal activity,
which relies on hemodynamic signal changes. In mice,
peripheral stimulation is accompanied by strong changes
in cardiovascular parameters eventually confounding
specific BOLD response. Non-vascular readouts could
constitute an alternative to study stimulus-evoked brain
activation. Here we propose to use spectroscopic imaging
in mice to visualize more specifically neurotransmitter
and metabolite changes associated to neural activation
in the respective brain region. Improved spatial and
temporal resolution allowed monitoring short term
changes occurring when applying e.g. electrical stimuli
to the mouse paw.
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