1H-MRS of Human Pancreas Grafts: Relaxation Times and Metabolite Concentrations
Jan Weis 1 , Lina Carlbom 1 , Lars Johansson 1 , Alireza Biglarnia 2 , Olle Korsgren 3 , and Hkan Ahlstrm 1
Department of Radiology, Oncology and
Radiation Science, Uppsala University, Uppsala, Sweden,
of Surgical Sciences, Uppsala University, Uppsala,
Department of Immunology, Genetics
and Pathology, Uppsala University, Uppsala, Sweden
1H-MRS of human pancreas grafts was performed using a
1.5 T scanner. The aim of the study was estimation of
pancreatic water, tCho, and lipid (-CH2-)n relaxation
times T1, T2, and absolute concentration of tCho and
fat. Spectra were processed by MRUI software package. T1
and T2 values were obtained by mono-exponential fitting
of spectral intensities versus repetition or echo times.
Knowledge of the relaxation times enables quantification
of pancreas metabolite concentrations using water as the
internal concentration reference. The pancreatic fat
content is useful for evaluation the pancreas graft
quality prior to transplantation.
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