Metabolic profiling of milk in preeclampsia patients & healthy controls: An in-vitro NMR study
Naranamangalam R Jagannathan 1 , Deepti Upadhyay 1 , Uma Sharma 1 , Kamini Dangat 2 , Anita Kilari 2 , Savita Mehendale 3 , Sanjay Lalwani 4 , and Sadhana Joshi 5
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
of Nutritional Medicine, Bharati Vidyapeeth University,
Pune, Maharashtra, India,
of Obstetrics and Gynecology, Bharati Vidyapeeth
University, Pune, Maharashtra, India,
of Pediatrics, Bharati Vidyapeeth University, Pune,
Vidyapeeth University, Pune, Maharashtra, India
Preeclampsia (PE) is a pregnancy specific syndrome and
is associated with vascular pathology which may affect
the lactogenesis. Proton NMR based metabolomics of milk
of PE mothers showed lower concentration of glycine and
glycerophosphocholine as compared to control women.
Glycine and glycerophosphocholine are known to be
associated with neurodevelopment of the infant and
alteration in levels of these metabolites may affect the
infants growth and particularly brain development.
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