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Abstract #1997

Assessing water influx and retention in the brain of AQP4 knockout mice by 17 O-MRI

Yifan Zhang 1 , Bernadette O Erokwu 2 , Yuchi Liu 1 , George W Farr 3,4 , Walter F Boron 4 , Chris A Flask 5,6 , and Xin Yu 4,5

1 Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2 Radiology, Case Western Reserve University, Cleveland, OH, United States, 3 Aeromics, LLC, Cleveland, OH, United States, 4 Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, 5 Biomedical Engineering and Radiology, Case Western Reserve University, Cleveland, OH, United States, 6 Pediatrics, Case Western Reserve University, Cleveland, OH, United States

In this study, oxygen-17 chemical shift imaging ( 17 O-CSI) was combined with a keyhole acquisition strategy to delineate the kinetics of H 2 17 O uptake and washout in mouse brains with high temporal resolution. The utility of the method was evaluated in a study comparing H 2 17 O uptake and retention in the brains of AQP4-knockout (AQP4-KO) and wildtype mice. The results showed that AQP4-KO led to decreased H 2 17 O uptake and retention but an unaltered rate of H 2 17 O washout.

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