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Abstract #2014

T2 Measurements of Childhood Brain Tumours and Metabolite Concentration Correction

Dominic Carlin 1,2 , Ben Babourina-Brooks 1,2 , Martin Wilson 1,2 , and Andrew C Peet 1,2

1 School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, 2 Birmingham Children's Hospital, Birmingham, United Kingdom

Metabolite concentrations are fundamental prognostic biomarkers, however measurement is known to be affected by T2 relaxation. Single-voxel MRS was performed using PRESS (TR 1500ms, TE 30/135ms) on a 1.5T scanner. Thirty-three childhood brain tumour patients and twenty-four healthy controls were analysed using TARQUIN for metabolite concentrations and T2 relaxation times were calculated. Concentrations were corrected for relaxation effects using metabolite and water T2 values and the importance of accurate T2 values was assessed. Significant differences in the T2 relaxation of water were found between tumour and normal brain and between tumour types which should be accounted for in metabolite quantification.

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