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Abstract #2020

Semi-Laser 5D Echo-Planar J-Resolved Spectroscopic Imaging: Pilot validation in Prostate Cancer

Zohaib Iqbal 1 , Neil E. Wilson 1 , Rajakumar Nagarajan 1 , Daniel A. Margolis 1 , Robert E. Reiter 2 , Steven S. Raman 1 , and Michael Albert Thomas 1

1 Radiological Sciences, University of California - Los Angeles, Los Angeles, California, United States, 2 Urology, University of California - Los Angeles, Los Angeles, California, United States

The purpose of this study was to validate a five dimensional spectroscopic imaging technique (3 spatial and 2 spectral dimensions) utilizing semi-Laser 180 pulses, called semi-Laser 5D Echo-Planar J-Resolved Spectroscopic Imaging (5D EP-JRESI), in the prostate of healthy volunteers and prostate cancer patients. This technique provides full coverage of the prostate. The results show that qualitative differences in the two-dimensional spectra (differences in citrate and choline) can be seen between a healthy location and an unhealthy location in a prostate cancer patient. This technique will continue to be evaluated in a larger number of healthy volunteers and cancer patients.

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