T2 prepared RUFIS: A new imaging paradigm for 3D whole-brain, silent and distortion-free BOLD fMRI
Ana Beatriz Solana Snchez 1 , Anne Menini 1 , Laura Sacolick 1 , Nicolas Hehn 1 , and Florian Wiesinger 1
GE Global Research, Garching bei Muenchen,
This work presents a novel T2-prepared RUFIS method that
tackles two eminent technical challenges of current BOLD
fMRI: acoustic noise and geometric distortions. The
method was tested and compared with GE-EPI and SE-EPI in
healthy volunteers scanned at 3T using a two-segment T2
prepared RUFIS approach in motor and auditory tasks.
Additionally, an improved approach using single-shot and
further reduced acoustic noise was tested. The method
showed a reduction of 40 dB(A) in LAeq acoustic noise
measurement with respect to EPI-based methods, lack of
geometrical distortions and consistent BOLD response,
less sensitive (~1.3% BOLD change) but apparently
spatially more specific.
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