Validation of in vivo structural template of human brainstem nuclei by fMRI at 7 Tesla
Marta Bianciardi 1 , Nicola Toschi 1,2 , Cornelius Eichner 1 , Kawin Setsompop 1 , Jonathan R. Polimeni 1 , Bruce R. Rosen 1 , and Lawrence L. Wald 1
Department of Radiology, A.A. Martinos
Center for Biomedical Imaging, MGH and Harvard Medical
School, Boston, MA, United States,
Physics Section, Department of Biomedicine and
Prevention, Faculty of Medicine, University of Rome Tor
Vergata, Rome, Italy
The aim of this work was to validate our recently
developed in-vivo structural template of human
brainstem-nuclei (Bn) of the ascending-arousal,
autonomic and motor systems by 1.1mm-isotropic fMRI at
7Tesla. For each of the 18 Bn-labels of the structural
template, a spatially matched functional parcel in the
brainstem was identified by ICA. Our results also showed
that structural Bn-labels were functionally connected to
specific brain regions as expected from previous work.
This work provides a preliminary validation of the
in-vivo structural Bn template, which is a key step
towards its use in future studies of human brainstem
function and pathology.
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