Abstract #2100
SEEP contrast highlights different functional connectivity networks compared to BOLD resting state fMRI
Venkatagiri Krishnamurthy 1 , Romeo S. Cabanban 2 , and Kaundinya S. Gopinath 1
1
Dept. of Radiology and Imaging Sciences,
Emory University, Atlanta, GA, United States,
2
Center
for Systems Imaging, Emory University, Atlanta, GA,
United States
Blood oxygen level dependent (BOLD) resting state fMRI
(rsFMRI) has been the most widely employed method to
explore resting-state functional connectivity (rsFC) in
brain networks. Signal enhancement by extravascular
protons (SEEP) has been advanced as an alternate
mechanism to assess brain activation. In this study we
compared rsFC networks highlighted by BOLD- and
SEEP-contrast rsFMRI. The results of this study show
that rsFMRI obtained with SEEP contrast exhibits
differential sensitivity to functional connectivity
networks compared to BOLD rsFMRI. While BOLD rsFC
networks exhibit higher sensitivity to state-dependent
brain networks (e.g. DMN), the SEEP contrast exhibits
higher sensitivity to anatomic connections.
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