Mapping effective connectivity in the mouse brain using Granger causality
Md Taufiq Nasseef 1,2 , Adam Liska 1,2 , Stefano Panzeri 1 , and Alessandro Gozzi 1
Center for Neuroscience and Cognitive
Systems @UniTn, Istituto Italiano di Tecnologia,
Rovereto, TN, Italy,
for Mind/Brain Sciences, University of Trento, Rovereto,
We have recently shown that the mouse brain contains
distributed resting-state fMRI (rsfMRI) networks
including a putative default-mode like network (DMN).
To map the direction of information flow within this
network, we have used Granger Causality (GC), a directed
measure of functional connectivity, to describe the
dominant direction of causation among four key nodes of
the mouse DMN. We provide evidence of directional
information transfer between nodes of this network that
replicate patterns recently described for the human DMN,
thus corroborating the presence of an evolutionary
conserved DMN precursor in the rodent brain.
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