Investigating the role of interictal activity during a natural stimulus presentation in children with epilepsy
Elhum A Shamshiri 1 , Maria Centeno 1 , Tim Tierney 1 , Kelly St Pier 2 , Ronit Pressler 2 , Suejen Perani 1,3 , Helen J Cross 4 , and David W Carmichael 1
Developmental Imaging and Biophysics
Section, UCL Institute of Child Health, London, United
Unit, Great Ormond Street Hospital, London, United
of Basic and Clinical Neurosciences, Institute of
Psychiatry, Psychology, and neuroscience, London, United
Unit, University College London, London, United Kingdom
Previously, cognitive network aberrations have been
shown in epilepsy patients with regards to resting state
networks such as the DMN (default mode network).
However, the influence of interictal activity on these
networks has yet to be properly explored. This study
uses EEG-fMRI to explore the effect of spikes as a
regressor of no interest in cognitive networks using a
general linear model (GLM) and functional connectivity.
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