Underestimation of functional connectivity with impaired cerebrovascular reserve : a working model of moyamoya disease
Tzu-chen Yeh 1,2 , Chou-ming Cheng 3 , Jin-jie Hong 2 , Sheng-che Hung 1 , Muh-Lii Liang 4 , and Jen-chuen Hsieh 2,3
Department of Radiology, Taipei Veterans
General Hospital, Taipei, Taiwan, Taiwan,
of Brain Science, National Yang-Ming University, Taipei,
Department of Medical
Research, Taipei Veterans General Hospital, Taipei,
Neurological Institute, Taipei Veterans General
Hospital, Taipei, Taiwan, Taiwan
Impaired cerebrovascular reserve (CVR) was supposed to
cause dissociation between functional integrity and
functional connectivity due to regional variation of
CVR. And reversed linearity between functional
connectivity and carbogen-based CVR suggested enhanced
or neuroplasticity in patients of moyamoya disease.
Underestimated or aberrant FC should be considered with
impaired CVR, and studies of FC in diseased states need
evidence of preserved CVR.
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