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Abstract #2129

Test-retest reproducibility of the BOLD response to a hypercapnic challenge

Bryon A. Mueller 1 , Nicholas Evanoff 2 , Kara L. Marlatt 2 , Justin R. Geijer 3 , Kelvin O. Lim 1 , and Donald R. Dengel 2

1 Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States, 2 School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, 3 Department of Health, Exercise and Rehabilitative Sciences, Winona State University, Winona, MN, United States

BOLD imaging during a hypercapnic challenge is often used to measure cerebral vascular reactivity. Determining the within and between day reproducibility of the BOLD signal change in response to a reproducible hypercapnic challenge will help determine if this method is precise enough to be used as a research tool to compare specific groups to control populations. We have measured the intraclass correlation coefficient and coefficient of within-subject variation for BOLD imaging during an iso-oxic, hypercapnic square stimulus. Results show excellent within day reproducibility and good between day reproducibility within the cerebral gray matter.

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