Marked perturbations in CBF and CO2 reactivity in subarachnoid hemorrhage
Yuhao Sun 1,2 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q. Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States,
of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai, China
Subarachnoid hemorrhage (SAH) is a medical emergency.
Vasospasm is widely reported. However, its effects on
cerebral blood flow (CBF) and cerebrovascular reactivity
are seldom studied. We found SAH induced marked
perturbations of basal CBF and cerebrovascular
reactivity in an established animal of SAH from day 0 to
7. CBF and cerebrovascular reactivity recovered
gradually by day 7. This study investigated the effects
of SAH on CBF and CO2 reactivity in an established rat
model. We concluded that hemodynamic disturbance in the
brain after subarachnoid hemorrhage could contribute to
progressive neurological deficits.
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