Development of a Porcine Middle Cerebral Artery Occlusion Stroke Model and Stroke Characterization with Quantitative MRI Techniques.
Shannon P. Holmes 1 , Simon R. Platt 2 , Liya Wang 3 , Vivian Lau 2 , Grace Harrison 2 , Hui Mao 3 , and Franklin West 2
Veterinary Biosciences & Diagnostic Imaging,
University of Georgia, Athens, GA, United States,
of Georgia, GA, United States,
University, GA, United States
Large animal models of stroke are needed for improved
translation of novel therapeutics. The pig has been
proposed as ideal, because of similar gyrification,
gray-white matter composition and size to the human
brain. This study developed a Landrace pig middle
cerebral artery occlusion (MCAO) model. Anatomic and
quantitative MRI techniques were used to evaluate the
stroke, including DWI, spectroscopy, DTI and PWI.
Anatomic studies, with DWI/ADC, measured the penumbra
and ischemic zone. Significant differences were detected
in neural metabolites and fractional anistrophy of white
matter. Therefore, the Landrace pig MCAO model is
feasible and produces in vivo quantifiable changes.
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