Can diffusion weighted MR spectroscopy be used in differentiating acute MELAS and acute stroke?
Dandan Zheng 1 , Bing Wu 1 , Jiangxi Xiao 2 , Zhenghua Liu 2 , and Zhenyu Zhou 1
GE Healthcare China, Beijing, Beijing,
Department, Peking University First Hospital, Beijing,
The underlying mechanism of neurological symptoms in
patients with mitochondrial myopathy, encephalopathy,
lactic acidosis, and stroke-like episodes (MELAS) is
still controversial. Signal abnormalities in
conventional MR contrast are indistinguishable from
those observed in stroke, especially in the acute stage.
In this study, diffusion weighted MR spectroscopy was
used to differentiate acute MELAS from acute stroke and
also to probe the mechanisms underlying the pathogenesis
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