Abstract #2177
Identification of neurovascular changes in cerebral amyloid angiopathy by modeling subject-specific hemodynamic response functions
Rebecca J Williams 1,2 , Bradley Goodyear 1,2 , Stefano Peca 3 , Cheryl R McCreary 1,2 , Richard Frayne 1,2 , Eric E Smith 1,2 , and G Bruce Pike 1,2
1
Radiology and Clinical Neurosciences,
Hotchkiss Brain Institute, University of Calgary,
Calgary, Alberta, Canada,
2
Seaman
Family MR Research Centre, Alberta Health Services,
Calgary, Alberta, Canada,
3
Tom
Baker Cancer Centre, University of Calgary, Calgary,
Alberta, Canada
Cerebral amyloid angiopathy (CAA) is an age-related
disease affecting the small blood vessels. Vascular
changes resulting from CAA have been detected using
fMRI, however modelling the hemodynamic response
function (HRF) may provide further information than BOLD
signal amplitude alone. Here we characterized the HRF in
CAA patients and healthy controls. Subject-specific HRFs
were estimated using the sum of two gamma functions
model. The time-to-peak (TTP) and full-width at
half-maximum (FWHM) of the positive response were
calculated from each subject's HRF and quantitatively
compared between groups. We found that the FWHM may be a
sensitive marker of CAA-related neurovascular changes.
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