Abstract #2186
Quantification of the local dynamic of the cerebrovascular autoregulation
Marco Piccirelli 1 , Bas van Niftrik 2 , Oliver Bozinov 2 , Athina Pangalu 1 , Antonios Valavanis 1 , Luca Regli 2 , and Jorn Fierstra 2
1
Neuroradiology University Hospital, Zurich,
ZH, Switzerland,
2
Neurosurgery
University Hospital, Zurich, ZH, Switzerland
To quantify the local cerebrovascular autoregulation in
function of the partial pressure of CO2 (PaCO2), we
combined quantitative cerebral flow measurements
obtained with ASL and cerebrovascular reactivity (CVR)
with BOLD fMRI. To control for PaCO2, a prospective end
tidal gas blender was used. This unique combination
during a capnic challenge in healthy subjects and steno
occlusive patients allows for the assessment of a
quantitative CVR curve and deliver a multi-parametric
map including cerebrovascular reactivity, reserve
capacity and mean cerebral blood flow measurements
during known hypocapnic and hypercapnic states.
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