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Abstract #2201

The abnormality of functional connectivity in Parkinsons in dopaminergic regions

Yue Xing 1 , Stefan Schwarz 1 , Nin Bajaj 2 , Penny Gowland 3 , and Dorothee Auer 1

1 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 Division of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom, 3 Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Differential functional connectivity patterns of anterior substantial nigra and posterior substantial nigra in Parkinsons were identified by comparing with age- and sex-matched healthy volunteers with seed-based analysis on cross-scanner resting state fMRI data. This abnormal functional connectivity reduction of the anterior and posterior substantial nigra in Parkinsons may suggest a link between posterior default-mode network impairment and dopaminergic deficit.

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