Microstructural Changes of Short Association Fibers in Parkinson's Disease and Normal Aging Assessed by Diffusion Tensor Imaging.
Jan Sedlacik 1 , Jan-Rdiger Schre 1,2 , Kai Boelmans 3 , and Jens Fiehler 1
University Medical Center Hamburg-Eppendorf,
Hamburg, Hamburg, Germany,
University of Ilmenau, Thringen, Germany,
Hospital of Wrzburg, Bayern, Germany
Frontal and central short association fibers (U-fibers)
were investigated by Diffusion Tensor Imaging (DTI) in
Parkinson's disease (PD) and healthy subjects. Healthy
age-related DTI changes were found in control subjects.
In detail, axial (AD), radial (RD) and mean diffusivity
(MD) increased in frontal and central fibers and
fractional anisotropy (FA) decreased in frontal but
increased in central fibers. Age matched healthy
controls showed slightly lower AD/RD/MD and higher FA as
compared to PD patients, which may suggest only a
marginal microstructural degeneration of U-fibers in PD
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