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Abstract #2212

Maximizing Tissue Contrast For MRI Evaluation of Parkinsons Disease

Silvia Mangia 1 , Philip Burton 1 , Igor Nestrail 1 , Mikko Nissi 1,2 , Alejandra Sierra 3 , Karin Shmueli 4 , Michael Howell 5 , Paul Tuite 5 , and Shalom Michaeli 1

1 CMRR, University of Minnesota, Minneapolis, Minnesota, United States, 2 University of Oulu, Oulu, Finland, 3 A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 4 University College London, London, United Kingdom, 5 Department of Neurology, University of Minnesota, Minneapolis, Minnesota, United States

The findings of this preliminary study support the use of advanced MRI methods based on adiabatic T1ρ, T2ρ RAFF4, QSM, DTI and rsfMRI to characterize the microstructural integrity and functional connectivity of Parkinsons disease (PD) subjects compared to healthy controls. Ultimately these methods may prove useful as a means to track the course of PD and potentially monitor the response to therapies.

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