Gadolinium-enhanced magnetic susceptibility contrast is reduced in the corpus callosum of a mouse model of Tauopathy
James O'Callaghan 1 , Holly Holmes 1 , Nicholas Powell 1 , Ozama Ismail 1 , Niall Colgan 1 , Jack Wells 1 , Bernard Siow 1 , Michael O'Neill 2 , Emily Collins 3 , Karin Shmueli 4 , and Mark Lythgoe 1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
Lilly & Co. Ltd, Windlesham, Surrey, United Kingdom,
Lilly and Company, Indianapolis, United States,
of Medical Physics and Biomedical Engineering,
University College London, London, United Kingdom
Alterations to white matter have been implicated in a
number of neurodegenerative diseases. In this work we
investigate the sensitivity of MRI magnetic
susceptibility mapping to these changes using a mouse
model of Tauopathy. A non-rigid registration of contrast
enhanced, high resolution ex vivo mouse brain images is
used to transform susceptibility maps into a common
space and a voxel-wise group comparison is performed.
Significant differences were observed that may indicate
disruption to the tissue of the corpus callosum.
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