Statistical Phase Noise Elimination for Amyloid Plaque Detection
Tetsuya Yoneda 1 , Koji Hashimoto 1 , Akihiko Kuniyasu 2 , Toshinori Hirai 1 , Mika Kitajima 1 , Mamoru Hashimoto 1 , Nan Kurehana 1 , Michiya Iwata 1 , Motohira Mio 3 , Sosuke Yoshinaga 1 , Hiroaki Terasawa 1 , Manabu Ikeda 1 , and Yasuyuki Yamashita 1
Kumamoto University, Kumamoto, Kumamoto,
University, Kumamoto, Japan,
University Chikushi Hospital, Fukuoka, Japan
In this study, we suggested statistical method to
effectively distinguish the signal of AP from phase
noise on MR-phase image resulting in reducing scan
duration for clinical application of diagnosis of AD.
Phase Difference Enhanced Imaging-image of human brain
showed dark rim sign expected as AP deposition but did
not show background phase noise containing iron
deposition due to aging by statistical noise
elimination. Our method may be applicable for clinical
image diagnosis for AD with reasonable scan duration
less than 4 min.
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