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Abstract #2223

Statistical Phase Noise Elimination for Amyloid Plaque Detection

Tetsuya Yoneda 1 , Koji Hashimoto 1 , Akihiko Kuniyasu 2 , Toshinori Hirai 1 , Mika Kitajima 1 , Mamoru Hashimoto 1 , Nan Kurehana 1 , Michiya Iwata 1 , Motohira Mio 3 , Sosuke Yoshinaga 1 , Hiroaki Terasawa 1 , Manabu Ikeda 1 , and Yasuyuki Yamashita 1

1 Kumamoto University, Kumamoto, Kumamoto, Japan, 2 Sojo University, Kumamoto, Japan, 3 Fukuoka University Chikushi Hospital, Fukuoka, Japan

In this study, we suggested statistical method to effectively distinguish the signal of AP from phase noise on MR-phase image resulting in reducing scan duration for clinical application of diagnosis of AD. Phase Difference Enhanced Imaging-image of human brain showed dark rim sign expected as AP deposition but did not show background phase noise containing iron deposition due to aging by statistical noise elimination. Our method may be applicable for clinical image diagnosis for AD with reasonable scan duration less than 4 min.

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