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Abstract #2233

Effect of Antiepileptic Treatment on Hippocampal Activity in Alzheimers Disease measured by ASL

Weiying Dai 1 , David C. Alsop 1 , and Daniel Z. Press 2

1 Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States, 2 Neurology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States

Increased hippocampal perfusion in early AD has been reported, but the underlying mechanism is still not clear. We hypothesized that epileptiform activity occurs in the hippocampus with AD and causes increased perfusion. Here, we designed a placebo-controlled study using an antiepileptic drug, Levetiracetam to modulate epileptic activity of the hippocampus. Nine subjects with AD were scanned following drug or placebo. We observed increased rather than decreased hippocampal perfusion with Levetiracetam. These findings suggest a more complex behavior of drug and epileptic activity effects in AD.

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