Abstract #2242
Early Tumor Response to Radiochemotherapy using 1D PRESS and 2D Correlated Spectroscopy
Xi Long 1,2 , Daniel Ramirez-Gordillo 1 , Huijun Liao 1 , Ben Rowland 1 , Jong-Woo Lee 3 , Nils Arvold 4 , Patrick Wen 4 , Srinivasan Mukundan 1 , Raymond Huang 1 , and Alexander P Lin 1
1
Center for Clinical Spectroscopy, Brigham
and Womens Hospital, Boston, MA, United States,
2
Radiology
Department, Union Hospital, Tongji Medical School,
Huazhong University of Science and Technology, Wuhan,
Hubei, China,
3
Department
of Neurology, Brigham and Womens Hospital, Boston, MA,
United States,
4
Division
of Neuro-Oncology, Brigham and Womens Hospital, Boston,
MA, United States
Non-invasive and quantitative, magnetic resonance
spectroscopy is ideally suited for treatment monitoring
in brain gliomas. Recent studies have demonstrated the
use of two-dimensional correlated spectroscopy (2D-COSY)
for the evaluation of multiple metabolites. The goal of
this study was to examine the efficacy of 2D-COSY
compared to conventional MRS for the evaluation of brain
tumors before and after radiochemotherapy. Our results
demonstrate that 2D-COSY method provides similar results
as 1D-MRS and can potentially provide additional
metabolic information that may impact therapy.
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