Prediction of progression free survival at 6 months in high grade gliomas using pre-chemoradiotherapy MRI
Lawrence Kenning 1 , Martin Lowry 1 , Martin Pickles 1 , Chris Rowland-Hill 2 , Shailendra Achawal 2 , Chittoor Rajaraman 2 , and Lindsay Turnbull 1
Centre for MR Investigations, Hull York
Medical School at University of Hull, Hull, United
and East Yorkshire Hospitals NHS Trust, United Kingdom
We investigated whether MR parameters measured
post-surgery prior to chemoradiotherapy could predict
progression free survival in high grade gliomas. DTI,
DSC and DCE data was acquired from 33 glioma patients
prior to chemoradiotherapy. Mean and standard deviations
were calculated for each parameter. Kaplan-Meier
survival analysis was calculated using dichotomised
parameter values. Results suggest that PK parameters
derived from DCE-MRI and diffusion tensor metrics prior
to adjuvant therapy predict progression-free survival.
Elevated values of Ktrans, ve and vb were all
significantly associated with a shorter progression-free
survival interval. Blood products may prevent DSC from
being clinically significant at this scan interval.
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