Characterising the Transition Zone from Tumor to Normal Brain in Glioblastomas using Multimodal MRI
Sarah A Leir 1 , Timothy J Larkin 1,2 , Natalie R Boonzaier 2,3 , Victoria Lupson 2 , Laila A Mohsen 4 , Adam Young 1 , and Stephen J Price 1,3
Division of Neurosurgery, Addenbrooke's
Hospital, Cambridge, Cambridgeshire, United Kingdom,
Brain Imaging Centre, Addenbrooke's Hospital, Cambridge,
Cambridgeshire, United Kingdom,
of Clinical Neurosciences, University of Cambridge,
Cambridge, Cambridgeshire, United Kingdom,
Department of Radiology, University of Cambridge,
Cambridge, Cambridgeshire, United Kingdom
Glioblastomas are one of the most lethal cancers to
affect humans. The efficacy of surgical resection and
radiotherapy, the mainstays of treatment, is limited by
our ability to accurately determine tumor margins.
Histological evidence suggests that there is a
transition zone from tumor to normal brain extending for
several centimeters beyond the T1 enhancing lesion.
Diffusion-based MR is a promising new imaging technique
to study tumor invasion. Using multimodal MR (DTI,
perfusion and spectroscopy), we identify, for the first
time, that biomarkers of tumor cell presence extend up
to 3 centimeters beyond the conventionally determined
and subsequently treated tumor margins.
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