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Abstract #2269

Study of contrast-enhanced T1-w MRI markers of cerebral radiation necrosis manifested in head-and-neck cancers, primary, and metastatic brain tumors: Preliminary findings

Prateek Prasanna 1 , Pallavi Tiwari 1 , Archana Siddalingappa 2 , Leo Wolansky 2 , Lisa Rogers 2 , Tai-Chung Lam 3 , Victoria To 3 , and Anant Madabhushi 1

1 Case Western Reserve University, Cleveland, OH, United States, 2 University Hospitals, Cleveland, OH, United States, 3 Tuen Mun Hospital, Hong Kong, China

In this work, we present the initial results of studying imaging differences of cerebral radiation necrosis on Gadolinium contrast-enhanced (Gd-C) T1-w MRI obtained from a unique cohort of patients treated for (a) nasopharyngeal carcinoma, (b) Glioblastoma Multiforme (GBM), and (c) metastatic brain tumors. Ability to identify changes in imaging characteristics on pure Radiation Necrosis (RN) with no cancer presence as observed in nasopharyngeal carcinoma, may allow for improved understanding of the changes in imaging characteristics on mixed RN on account of cancer presence in primary and metastatic brain tumors

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