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Abstract #2304

Extra-ocular muscle fat fraction in thyroid eye disease

Tilak Das 1 , Andrew J Patterson 1 , Paul Meyer 2 , Rachna Murthy 2 , and Martin J Graves 1

1 Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 2 Dept of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Thyroid eye disease is an autoimmune disorder of orbital tissues that can cause extra-ocular muscle inflammation and enlargement. Fat infiltration of extra-ocular muscles occurs in patients with chronic disease. Quantification of fat in extra-ocular muscles has not been previously described. The purpose of this study was to evaluate the application of fat fraction measurements to extra-ocular muscles in healthy volunteers and patients with thyroid eye disease. Mean fat fraction was significantly greater in thyroid eye disease patients (p=0.021). This study demonstrates the feasibility of measuring fat fraction in extra-ocular muscles as well as detecting differences between groups.

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