Extra-ocular muscle fat fraction in thyroid eye disease
Tilak Das 1 , Andrew J Patterson 1 , Paul Meyer 2 , Rachna Murthy 2 , and Martin J Graves 1
Department of Radiology, Cambridge
University Hospitals NHS Foundation Trust, Cambridge,
of Ophthalmology, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, United Kingdom
Thyroid eye disease is an autoimmune disorder of orbital
tissues that can cause extra-ocular muscle inflammation
and enlargement. Fat infiltration of extra-ocular
muscles occurs in patients with chronic disease.
Quantification of fat in extra-ocular muscles has not
been previously described. The purpose of this study was
to evaluate the application of fat fraction measurements
to extra-ocular muscles in healthy volunteers and
patients with thyroid eye disease. Mean fat fraction was
significantly greater in thyroid eye disease patients
(p=0.021). This study demonstrates the feasibility of
measuring fat fraction in extra-ocular muscles as well
as detecting differences between groups.
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