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Abstract #2306

Measurement of the Vitreous Humour Deformation and Strain with Tagged MR Imaging

Ming Li 1,2 , Paul Gamlin 3 , Mark S. Bolding 4,5 , Ronald J. Beyers 1 , Nouha Salibi 1,6 , Xiaoxia Zhang 1,2 , and Thomas S. Denney Jr. 1,2

1 Auburn University MRI Research Center, Auburn University, Auburn, AL, United States, 2 Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 3 Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, United States, 4 Departments of Radiology, Vision Sciences, and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States, 5 Civitan Functional Neuroimaging Laboratory, University of Alabama at Birmingham, Birmingham, AL, United States, 6 MR R&D, Siemens Healthcare, Malvern, PA, United States

The vitreous humour undergoes mechanical changes that are thought to be related to a range of pathologies including retinal detachment and are reflected on the motion pattern of the vitreous humour during eye movements. We analyzed the in-vivo dynamics of the vitreous humour under smooth pursuit eye movement, using tagged MRI with a standard head coil in a 7 Tesla scanner. We also propose a method for measuring regional shear strain in the vitreous humour, which does not use assumptions on the geometry of the globe or material properties of the vitreous.

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