The effects of Dorzolamide on retinal and choroidal blood flow in a mouse glaucoma model
Saurav B Chandra 1 , Kaiwalya S Deo 1 , Eric R Muir 1 , Jeffrey W Kiel 2 , and Timothy Q Duong 1
Research Imaging Institute, UT Health Sc.
Center, San Antonio, San Antonio, Texas, United States,
UT Health Sc. Center, San Antonio, San Antonio, Texas,
Dorzolamide (DZ) is clinically used to treat glaucoma by
reducing intraocular pressure, which could affect blood
flow to the eye. The goal of this study was to
investigate the effect of topical DZ application on
retinal and choroidal blood flow in DBA/2J mice, an
established mouse model of glaucoma at different stages
of severity. DZ was found to induce measurable and
sustained effects in choroidal BF and retinal BF at up
to 2 hours post DZ application in late stage glaucoma
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