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Abstract #2307

The effects of Dorzolamide on retinal and choroidal blood flow in a mouse glaucoma model

Saurav B Chandra 1 , Kaiwalya S Deo 1 , Eric R Muir 1 , Jeffrey W Kiel 2 , and Timothy Q Duong 1

1 Research Imaging Institute, UT Health Sc. Center, San Antonio, San Antonio, Texas, United States, 2 Ophthalmology, UT Health Sc. Center, San Antonio, San Antonio, Texas, United States

Dorzolamide (DZ) is clinically used to treat glaucoma by reducing intraocular pressure, which could affect blood flow to the eye. The goal of this study was to investigate the effect of topical DZ application on retinal and choroidal blood flow in DBA/2J mice, an established mouse model of glaucoma at different stages of severity. DZ was found to induce measurable and sustained effects in choroidal BF and retinal BF at up to 2 hours post DZ application in late stage glaucoma mice.

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