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Abstract #2327

A Simplified Spin and Gradient Echo (SAGE) Approach for Brain Tumor Perfusion Imaging

Ashley M Stokes 1 and C. Chad Quarles 1

1 Institute of Imaging Science, Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Contrast agent leakage in tumors can severely reduce the reliability of DSC perfusion measures due to competing T 1 effects. While dual gradient-echo (GE) sequences can provide robust T 1 -insensitive GE hemodynamic measures, no analogous method exists for T 1 -insensitive spin-echo (SE) measures. Here, we propose a simplified spin- and gradient-echo (sSAGE) approach that utilizes a combined dual GE and SE sequence and an analytical solution for T 1 -insensitive ∆R 2 * and ∆R 2 timecourses. As this approach only requires acquisition and storage of three echoes and does not rely upon computationally demanding non-linear fitting, it could facilitate more rapid clinical translation and adoption of SAGE-based DSC-MRI.

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