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Abstract #2344

Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow

Shin-Lei Peng 1,2 , Pan Su 1,3 , Fu-Nien Wang 2 , Yan Cao 4 , Rong Zhang 5 , Hanzhang Lu 1,3 , and Peiying Liu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 3 Biomedical Engineering Graduate Program, UT Southwestern Medical Center, TX, United States, 4 Department of Mathematical Sciences, University of Texas at Dallas, Richardson, TX, United States, 5 Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, United States

PC-MRI is a noninvasive technique for quantifying whole-brain CBF. However, PC-MRI measured velocity map is susceptible to partial voluming, leading to biases in CBF estimation. This work firstly aimed to optimize in-plane resolution of PC-MRI for CBF quantification. Furthermore, we assessed effects of non-perpendicular imaging slice orientation on CBF quantification. Results showed in-plane resolution of 0.5 mm could serve as an optimal protocol for quantifying whole-brain CBF. Moreover, non-perpendicular positioning of the imaging slice on the targeted artery could result in overestimated CBF. But if the slice orientation is within 10X of the ideal angulation, the bias is negligible.

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