Abstract #2365
MRI based quantification of cortical responses to exercise
Andrew P Hale 1 , Charlotte E Buchanan 1 , Johannes van Lieshout 2 , Penny A Gowland 1 , Paul L Greenhaff 3 , and Sue T Francis 1
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, United Kingdom,
2
School
of Biomedical Sciences, University of Nottingham,
Nottingham, United Kingdom,
3
Faculty
of Medicine & Health Sciences, University of Nottingham,
Nottingham, United Kingdom
Low to moderate intensity dynamic exercise in healthy,
young individuals has been directly linked to enhanced
cerebral neuronal activity. Here we assess the
feasibility of using MRI to measure global and regional
changes in CBF to steady-state exercise. We demonstrate
that it is possible to assess global and regional brain
responses to exercise involving a large muscle mass at
workloads of up to 50%VO2max. Moreover, at low intensity
workloads (30%VO2max) it appears that there is an
uncoupling of regional blood flow from brain activity,
suggesting that cardiac output is the primary
determinant of regional brain blood flow under these
conditions.
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