In vivo rapid 3D Microscopic DTI combining Super Resolution Reconstruction and Reverse Gradient correction method

Super Resolution Reconstruction is performed on 2D EPI distorted diffusion images acquired in vivo on brain mouse at 9.4T. At this field, the feasibility to correct severe distortions with Reverse Gradient method is proved. Based on three orthogonal low resolution DTI acquisition (120*120*360 m3), SRR is successfully performed allowing the calculation of 3D isotropic high spatial resolution DTI (120*120*120 m3). Thus, high spatial resolution DTI parameter maps can be visualized. Fibertracking is also computed and fine white matter structures such as the fornix can be rebuilt.

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