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Abstract #2592

Diffusion tensor MRI of hearts with chronic infarct in multiple mechanical states

Maelene Lohezic 1 , Remi Peyronnet 2 , Craig A. Lygate 3 , Debra McAndrew 3 , Irvin Teh 1 , Peter Kohl 2,4 , and Jurgen E. Schneider 1

1 BMRU, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2 National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4 Department of Computer Science, University of Oxford, Oxford, United Kingdom

Myocardial microstructure is closely related to cardiac function in health and disease, and can be assessed by diffusion tensor imaging (DTI) throughout the cardiac cycle in a non-destructive manner. We investigated changes in DTI parameters in live isolated chronically-infarcted rat hearts in three mechanical states. Significant increase in the mean apparent diffusion coefficient was observed in infarcted hearts in the contractured state, while significant decrease in fractional anisotropy was observed in infarcted hearts in all three states. Furthermore, differences in primary myocyte orientations were observed between healthy hearts and the remote zone of infarcted hearts in the relaxed state.

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